GENUS NAME: alendronate
BRANDNAME: Fosamax, Binosto
DRUG COURSE AND MECHANISM: Alendronate is in a category of drugs called bisphosphonates. The bisphosphonate course contains etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), and tiludronate (Skelid). Bisphosphonates are useful for treating osteoporosis (decreased density of bone that results in breaks) and bone pain from ailments including metastatic breast cancer, multiple myeloma, and Paget’s dis Ease. Bony tissue is in a continual state-of re-modeling. New bone is laid down by cells called osteoblasts while bone is removed by cells called osteoclasts. Bisphosphonates reinforce bone by inhibiting bone removal (resorption) by osteoclasts. After menopause, there’s a heightened rate of bone loss and was proven to improve bone mineral density and reduce fractures of bones.
Fosamax Side Effects
The most frequently encountered complication of alendronate is gut pain.
Other significant negative effects are:
Black fecal matter (due to intestinal bleeding),
Change in flavor perception, and
Muscle or joint.
Might irritate the esophagus, creating hemorrhage. This happens more frequently when patients don’t drink water wait half an hour before lying down, or simply take alendronate prior to the primary meal of the day. Infrequently, individuals may experience jaw issues (osteonecrosis of the jaw) correlated with delayed healing and disease after tooth extraction.
The recommended dosage for therapy of osteoporosis is 5-10 mg daily or 35-70 mg. Paget’s disease is treated with 40 milligrams once daily for half a year.
Foods, other medicines, and vitamins can hinder the absorption of alendronate, they need to be taken half an hour before alendronate. So that you can prevent chemical irritation of the esophagus (the swallowing tube which connects the mouth with all the stomach), alendronate ought to be used using a complete glass of plain water immediately upon arising in the morning and not chewed or sucked. It needs to be prevented by individuals with abnormalities of the esophagus which delay esophageal emptying, including scarring (stricture) or inadequate motility (achalasia). Patients should additionally not lay down for half an hour after swallowing the pills. Those patients that cannot stay upright for a minimum of half an hour after taking alendronate must not take it.
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