Cymbalta is the generic brand for duloxetine. Cymbalta is an anti-depressant which belong to a class of drugs known as serotonin-norepinephrine reuptake inhibitors. Cymbalta is a prescription drug used for treating depression. Cymbalta acts by increasing the amount of neurotransmitters serotonin and norepinephrine which helps to regulate blood and may block pain signals going through the brain. Doctors also prescribe Cymbalta for treating anxiety that lasts up to 6months, pain from diabetic nerve damage, long-term muscle pain and bone pain. Cymbalta can also ease pain common with osteoarthritis.

Cymbalta and weight gain

Cymbalta is an anti-depressant and it causes variations in weight. At the start of Cymbalta medication, patients might experience weight loss which is a common side effect of Cymbalta but after taking Cymbalta for a long time, there is an increase in weight gain.

Cymbalta Dose and Dosage Forms

Cymbalta comes in 20mg, 30mg and 60mg doses of blue and white, blue and yellow, and green flavors. The recommended dosage of Cymbalta for depression is 40 to 60mg a day. For patients suffering from diabetic nerve pain, anxiety, muscle or bone pain; the recommended dosage is 60mg a day. Swallow the capsule whole, do not crush or open the capsule. Cymbalta can be taken with or without food.

Side Effects of Cymbalta

Common side effects of Cymbalta medication include: nausea, dry mouth, sleepiness, tiredness, constipation, sweating, head and muscle ache, diarrhea, vomiting, headache, loss of interest in sex, increased urination, weakness, dizziness and tremor. Contact your doctor immediately you experience any of these severe side effects: abdominal pain, dark or colored urine, extreme weakness, difficult breathing, fever with sweating, chest pain, panic attack, worsening depression and swelling of the face, lip and tongue.

Inform your doctor about other medications you are taking before you start Cymbalta medication; this includes illegal drugs, over the counter herbs or supplements. Patients on blood thinners, other antidepressants, over the counter pain medication, diuretics, heart and blood pressure medication, heartburn medication and some antibiotics like ciprofloxacin should inform their doctor of all these medications before starting Cymbalta medication. Patients with a history of liver and eye problems, high blood pressure, seizures, bipolar disorder, kidney disease, abnormal disease and family history of suicide should take Cymbalta with caution. Patients should also inform their doctor if they have any allergies to medication; including anti- depressants.


Do not stop Cymbalta medication abruptly without informing your doctor first. Withdrawal symptoms are nausea, vomiting, anxiety, dizziness, headache, sweating, sleeping difficulty and nightmares. Patients suffering from a condition called uncontrolled narrow-angle glaucoma should not take Cymbalta; cymbal worsens glaucoma symptoms.
Do not take Cymbalta with alcohol; Alcohol increases side effects of Cymbalta. Also, patients suffering from liver disease should not take Cymbalta; Cymbalta may cause liver damage.